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Showing 1–2 of 2 results
Advanced filters: Author: Banafsheh Etemad Clear advanced filters

  • The spindle assembly checkpoint protects against premature chromosome segregation during mitosis but it is not known whether microtubule attachment to the kinetochore, or force generated from this interaction, is being monitored. Here the authors uncouple these processes and show that microtubule attachment is sufficient to satisfy the checkpoint.

    • Banafsheh Etemad
    • Timo E. F. Kuijt
    • Geert J. P. L. Kops
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Nazneen Rahman, Geert Kops and colleagues report the identification of biallelic loss-of-function mutations in TRIP13 in six individuals with Wilms tumor who presented with features of mosaic variegated aneuploidy. They show that TRIP13-mutant cells show spindle assembly checkpoint defects and suggest that mechanisms leading to aneuploidy may contribute directly to increased cancer risk.

    • Shawn Yost
    • Bas de Wolf
    • Nazneen Rahman
    Research
    Nature Genetics
    Volume: 49, P: 1148-1151