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Acta Pharmacologica Sinica (10)
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Nature Microbiology (1)

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Showing 1–12 of 12 results

Advanced filters: Author: Bao-Xue Yang Clear advanced filters

Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

Jian-hua Ran
Min Li
Bao-xue Yang
Research30 May 2016
Acta Pharmacologica Sinica

Volume: 37, P: 973-983
An orally available M^pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

An inhibitor of the SARS-CoV-2 main protease (Mpro), Y180, showed therapeutic efficacy against wild-type SARS-CoV-2 and its variants including Omicron after oral administration and improved survival in a humanized mouse model.

Bao-Xue Quan
Huiping Shuai
Shengyong Yang
Research27 Apr 2022
Nature Microbiology

Volume: 7, P: 716-725
Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Here, authors present cryo-EM structures and simulations of urea transporter members in resting-, transport-, or inactive-states bound with synthetic competitive, uncompetitive or noncompetitive inhibitor.

Shen-Ming Huang
Zhi-Zhen Huang
Jin-Peng Sun
ResearchOpen Access26 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease

Dan-dan Zhong
Cheng Hu
Ying Sun
Research17 Oct 2025
Acta Pharmacologica Sinica

P: 1-12
Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Jia Meng
Sai-zhen Wang
Bao-xue Yang
Research07 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 782-790
Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3

Shen-ming Huang
Bo-yang Cai
Jin-peng Sun
Research16 Jun 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2989-2997
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

Xiao-wei Li
Jian-hua Ran
Bao-xue Yang
Research29 Jul 2022
Acta Pharmacologica Sinica

Volume: 44, P: 406-420
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Abudumijiti Abulizi
Ling Hu
Bao-xue Yang
Research29 Apr 2021
Acta Pharmacologica Sinica

Volume: 42, P: 1703-1713
A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters

Min Li
Yan Zhao
Bao-xue Yang
Research18 Jun 2019
Acta Pharmacologica Sinica

Volume: 41, P: 65-72
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiao-qiang Geng
Ang Ma
Bao-xue Yang
Research05 Dec 2019
Acta Pharmacologica Sinica

Volume: 41, P: 670-677
Drug development in targeting ion channels for brain edema

Zheng-wei Luo
Andrea Ovcjak
Hong-shuo Sun
Reviews27 Aug 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1272-1288
Drug discovery for polycystic kidney disease

Ying Sun
Hong Zhou
Bao-xue Yang
Reviews03 Jun 2011
Acta Pharmacologica Sinica

Volume: 32, P: 805-816