Nature Search

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics

Non-invasive methods to predict treatment response are urgently needed. Here in lung cancer, the authors develop a single-cell on-chip cytometry method to metabolically phenotype disseminated tumor cells, revealing metabolic heterogeneity and predictors of therapy response and survival.

Ziming Li
Zhuo Wang
Qihui Shi
ResearchOpen Access26 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era

The emission allocation strategies of global scenarios do not specify the potential benefits from extra climate mitigation efforts. Here the authors show that compared to the current Nationally Distributed Contributions, the proposed self-preservation strategy might generate 126–616 trillion dollars of additional benefits by 2100.

Yi-Ming Wei
Rong Han
Zili Yang
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1

Guoqing Su
Jinghang Qian
Liu Yang
ResearchOpen Access07 Aug 2025
Cell Death & Disease

Volume: 16, P: 1-18
Identification of the optimal candidates to benefit from surgery and chemotherapy among elderly female breast cancer patients with bone metastases

Yuchen Hu
Junfeng Tang
Qing Gao
ResearchOpen Access08 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and succinylation

Rong Chen
Jiantao Hu
Baojun Min
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: Integrated study on the comprehensive magnetic-field configuration performance in the 150 kW superconducting magnetoplasmadynamic thruster

Jinxing Zheng
Haiyang Liu
Boqiang Zhao
Amendments and CorrectionsOpen Access10 Nov 2021
Scientific Reports

Volume: 11, P: 1
SEL1L preserves CD8⁺ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis

Yafeng Gao
Wenhui Li
Lianjun Zhang
Research30 Aug 2023
Cellular & Molecular Immunology

Volume: 20, P: 1232-1250
Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter

Huahua Zhang
Jiming Han
Chen Huang
ResearchOpen Access08 May 2023
Cell Death Discovery

Volume: 9, P: 1-11
Integrated study on the comprehensive magnetic-field configuration performance in the 150 kW superconducting magnetoplasmadynamic thruster

Jinxing Zheng
Haiyang Liu
Boqiang Zhao
ResearchOpen Access19 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Biophotonic probes for bio-detection and imaging

The emerging biological entities-based biophotonic probes, such as biological lasers, biophotonic waveguides, and bio-microlenses, have opened up an entirely new window for bio-detection and imaging with high biocompatibility.

Ting Pan
Dengyun Lu
Baojun Li
ReviewsOpen Access09 Jun 2021
Light: Science & Applications

Volume: 10, P: 1-22

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