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Showing 1–4 of 4 results
Advanced filters: Author: Baptiste Guey Clear advanced filters

  • Using cryo-electron microscopy, the authors determine the structure of cGAS bound to nucleosomes and present evidence for the mechanism by which nucleosome binding to cGAS prevents cGAS dimerization and its binding to free double-stranded DNA.

    • Ganesh R. Pathare
    • Alexiane Decout
    • Andrea Ablasser
    Research
    Nature
    Volume: 587, P: 668-672

  • Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

    • Baptiste Guey
    • Andrea Ablasser
    News & Views
    Nature Immunology
    Volume: 20, P: 1418-1420