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Showing 1–9 of 9 results
Advanced filters: Author: Bart Jan Kullberg Clear advanced filters

  • Common genetic variants can affect an individual’s immune response to pathogens. Here, the authors uncover and characterize variants regulating cytokine responses in Lyme Borreliosis in 1,060 patients.

    • Javier Botey-Bataller
    • Hedwig D. Vrijmoeth
    • Yang Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Candidaemia is a common cause of bloodstream infection, but the genetic basis of Candidainfection is poorly understood. Here, the authors identify genetic variation at three loci that increase risk of candidaemia, and show that genes at these loci have a role in antifungal host defence.

    • Vinod Kumar
    • Shih-Chin Cheng
    • Mihai G. Netea
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • Systemic infection with the fungal pathogenC. albicans is characterized by high mortality, and the precise antifungal defence mechanisms in humans are poorly defined. Using a systems approach, Smeekens et al. describe a previously unknown role for type I interferons in human anti-Candidadefence.

    • Sanne P. Smeekens
    • Aylwin Ng
    • Ramnik J. Xavier
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • This Review describes the host immune response toCandida fungal infections. The authors detail the innate and adaptive immune mechanisms, as well as the non-immune mechanisms, that are involved in the antifungal response. They also discuss emerging evidence suggesting that both innate and adaptive immune cells contribute to immune memory against Candidaspecies.

    • Mihai G. Netea
    • Leo A. B. Joosten
    • Frank L. van de Veerdonk
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 630-642

  • Recognition of fungi by the innate immune system depends on 'tasting' several pathogen-associated molecular patterns in the fungal cell wall. In this Review, the authors pull together the availablein vitro and in vivo data to propose an integrated model for Candida albicansrecognition by the innate immune system.

    • Mihai G. Netea
    • Gordon D. Brown
    • Neil A. R. Gow
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 67-78

  • Candida spp. are common commensal organisms in the gut microbiota. However, breaches in the intestinal barrier, an impaired immune system, the use of broad-spectrum antibacterial agents and other interventions associated with medical progress can promote invasive Candida spp. infections, including bloodstream infections, that are often fatal.

    • Peter G. Pappas
    • Michail S. Lionakis
    • Bart Jan Kullberg
    Reviews
    Nature Reviews Disease Primers
    Volume: 4, P: 1-20