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Showing 1–7 of 7 results
Advanced filters: Author: Baruch I. Kanner Clear advanced filters

  • Neurotransmitter:sodium symporters (NSS) use energy derived from sodium gradients to power transport of their respective neurotransmitters. But, whereas most eukaryotic NSS transporters are chloride-dependent, the prokaryotic homologue LeuT is not. Structural and mechanistic knowledge of LeuT, and a chloride transporter from an entirely different family, is applied to mammalian NSS transporters and finds that transported chloride ions serve to neutralise the positive charge carried by the sodium ions.

    • Elia Zomot
    • Annie Bendahan
    • Baruch I. Kanner
    Research
    Nature
    Volume: 449, P: 726-730

  • Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.

    • Baruch I Kanner
    News & Views
    Nature Structural & Molecular Biology
    Volume: 20, P: 1142-1144

  • There are no sequential snapshots of a transporter protein as it mediates the simultaneous passage of ions and solutes into a cell. Comparing different snapshots of structurally related transporters offers fascinating insights.

    • Baruch I. Kanner
    News & Views
    Nature
    Volume: 454, P: 593-594

  • The GABA transporters (GATs) enforce spatiotemporal control of the inhibitory neurotransmitter GABA at neural synapses. Nayak et al. report the structure of substrate-bound GAT1 in an ion-bound cytosol-facing conformation, providing mechanistic insights into GABA selection and reuptake.

    • Smruti Ranjan Nayak
    • Deepthi Joseph
    • Aravind Penmatsa
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1023-1032

  • Sodium-coupled neurotransmitter transporters are essential for neurons to communicate. The high-resolution crystal structure of a bacterial relative hints at how this family of transporters works.

    • Baruch I. Kanner
    News & Views
    Nature
    Volume: 437, P: 203-205