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Showing 1–3 of 3 results
Advanced filters: Author: Battsetseg Batchuluun Clear advanced filters

  • Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.

    • Jaya Gautam
    • Jianhan Wu
    • Gregory R. Steinberg
    ResearchOpen Access
    Nature
    Volume: 645, P: 507-517

  • GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.

    • Dongdong Wang
    • Logan K. Townsend
    • Gregory R. Steinberg
    ResearchOpen Access
    Nature
    Volume: 619, P: 143-150

  • De novo lipogenesis (DNL) is vital for the maintenance of whole-body and cellular homeostasis, but aberrant upregulation of the pathway is associated with a broad range of conditions, including cardiovascular disease, metabolic disorders and cancers. Here, Steinberg and colleagues provide an overview of the physiological and pathological roles of the core DNL enzymes and assess strategies and agents currently in development to therapeutically target them.

    • Battsetseg Batchuluun
    • Stephen L. Pinkosky
    • Gregory R. Steinberg
    Reviews
    Nature Reviews Drug Discovery
    Volume: 21, P: 283-305