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Showing 1–5 of 5 results
Advanced filters: Author: Bauer L. LeSavage Clear advanced filters

  • Maintaining neural progenitor cell stemness has proven challenging in vitro, due to their propensity to form cell-dense neurospheres. Here, the authors developed a 3D hydrogel system that supports neural progenitor cell stemness maintenance and differentiation by tuning matrix mechanics and cell-binding cues, enabling long-term expansion and neuron formation without needing dense cell clusters.

    • Michelle S. Huang
    • Bauer L. LeSavage
    • Sarah C. Heilshorn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodelling in a synthetic hydrogel platform.

    • Bauer L. LeSavage
    • Sarah C. Heilshorn
    News & Views
    Nature Materials
    Volume: 20, P: 124-125

  • This Review summarizes limitations in the current techniques used for patient-derived cancer organoid culture and highlights recent advancements and future opportunities for their standardization.

    • Bauer L. LeSavage
    • Riley A. Suhar
    • Sarah C. Heilshorn
    Reviews
    Nature Materials
    Volume: 21, P: 143-159