Nature Search

Multicohort assessment of plasma metabolic signatures of tuberculosis disease in children: a retrospective cross-sectional study

Mary M. Nellis
Juaneta Luiz
Vidya Mave
ResearchOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-11
Ebola vaccine safe for mothers and infants

A clinical trial of pregnant women provides critical safety and immunogenicity data in support of a two-dose Ebola vaccine regimen — and reinforces the importance of maternal immunization research, urgently needed for other preventable diseases.

Beate Kampmann
Alice Hucko
News & Views09 Oct 2025
Nature Medicine

Volume: 31, P: 3618-3619
Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa

Jagne, Jobe et al. assess the SARS-CoV-2-specific immune landscape of people in The Gambia exposed to the pre-Delta variant in July 2021. SARS-CoV-2 infection induces T cell, mucosal, and systemic antibody responses, with variations observed across these immune compartments.

Ya Jankey Jagne
Dawda Jobe
Beate Kampmann
ResearchOpen Access16 May 2025
Communications Medicine

Volume: 5, P: 1-10
Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice

Ziyin Wang
Miko Zhong
John S. Tregoning
ResearchOpen Access31 Dec 2024
npj Viruses

Volume: 2, P: 1-10
High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia

Many low- and middle-income countries, including The Gambia, had low COVID-19 vaccination coverage during the emergence of the Delta and Omicron variants. Here, the authors perform a prospective household cohort study in the Gambia to investigate the dynamics of SARS-Cov-2 infection in this setting.

Sheikh Jarju
Rhys D. Wenlock
Thushan I. de Silva
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-10
Publisher Correction: Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

Alexander J. Keeley
Fatoumata E. Camara
Thushan I. de Silva
Amendments and CorrectionsOpen Access24 Sept 2025
Nature Medicine

Volume: 31, P: 3570
Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

Serological profiles from two observational cohort studies in The Gambia characterize surrogates of protection against Streptococcus pyogenes and reveal an antibody response against antigens that are currently in vaccine development.

Alexander J. Keeley
Fatoumata E. Camara
Thushan I. de Silva
ResearchOpen Access08 Aug 2025
Nature Medicine

Volume: 31, P: 3360-3371
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.

Amy H. Lee
Casey P. Shannon
Tobias R. Kollmann
ResearchOpen Access12 Mar 2019
Nature Communications

Volume: 10, P: 1-14
DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life

Evaluating the immune status of newborns helps recognition of those who are at higher risk for serious infectious diseases. Here authors identify lower, epigenetically inferred,
neutrophil-to-lymphocyte ratios during the first week of life as risk factor for sepsis and provide insight into the underpinning epigenetic and transcriptional patterns.

David Martino
Nina Kresoje
Tobias R. Kollmann
ResearchOpen Access17 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Women and children last? Shaking up exclusion criteria for vaccine trials

Is it time to shift to a model of ‘inclusion unless otherwise justified’ in trials of vaccines for pandemics?

Beate Kampmann
Comments & Opinion13 Jan 2021
Nature Medicine

Volume: 27, P: 8
Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants

Oral rotavirus vaccine (ORV) efficacy varies between countries, but underlying reasons aren’t fully understood. In this prospective cohort study, authors show that maternal rotavirus-specific antibodies in serum and breastmilk and pre-vaccination microbiota diversity are negatively correlated with ORV response in India and Malawi but not in the UK.

Edward P. K. Parker
Christina Bronowski
Miren Iturriza-Gómara
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023

A survey of 23,000 adults in 23 countries in 2023 reports that the pandemic experience reduced participants’ willingness to be vaccinated for COVID-19 and receive routine vaccinations and reduced trust in recommendations from public health authorities.

Jeffrey V. Lazarus
Trenton M. White
Ayman El-Mohandes
ResearchOpen Access29 Apr 2024
Nature Medicine

Volume: 30, P: 1559-1563
Keeping track of the SARS-CoV-2 vaccine pipeline

This Web Watch introduces the VaC tracker, a web resource that features an overview of the COVID-19 ‘vaccine landscape’, a clinical trials database and a ‘living review’ that distils the results of vaccine trials as they become available.

Edward P. K. Parker
Madhumita Shrotri
Beate Kampmann
Research Highlights28 Sept 2020
Nature Reviews Immunology

Volume: 20, P: 650
Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis

Nicholas J. Andreas
Robindra Basu Roy
Beate Kampmann
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-11
Respiratory syncytial, parainfluenza and influenza virus infection in young children with acute lower respiratory infection in rural Gambia

Grant A. Mackenzie
Aminata Vilane
Adam Meijer
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Immunization: vital progress, unfinished agenda

An overview of the effects of vaccines on global morbidity and mortality, vaccine safety issues, and the hurdles involved in proceeding from vaccine discovery to successful implementation.

Peter Piot
Heidi J. Larson
Beate Kampmann
Reviews06 Nov 2019
Nature

Volume: 575, P: 119-129
Acquisition and carriage of genetically diverse multi-drug resistant gram-negative bacilli in hospitalised newborns in The Gambia

Bah, Kujabi et al. characterise multi-drug resistant-Gram negative bacilli (MDR-GNB) carriage in small vulnerable newborns and their mothers at a low-resource African hospital. Many neonates acquire MDR and ESBL-GNB between birth and 7 days of age, but there is only limited evidence these are transmitted from the mothers.

Saikou Y. Bah
Mariama A. Kujabi
Helen Brotherton
ResearchOpen Access03 Jun 2023
Communications Medicine

Volume: 3, P: 1-10
Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries

Elizabeth Whittaker
Mark P. Nicol
Beate Kampmann
ResearchOpen Access17 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India

Sudhir Babji
Punithavathy Manickavasagam
Holm H. Uhlig
ResearchOpen Access23 Mar 2020
npj Vaccines

Volume: 5, P: 1-8
Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India

Edward P. K. Parker
Ira Praharaj
Nicholas C. Grassly
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary

On 27–29^th of September 2022, Wellcome convened an international multi-stakeholder workshop to discuss the use of Correlates of Protection (CoP) to accelerate vaccine development, the hybrid format meeting was attended by 80 delegates including developers, manufacturers, regulators, public health officials and policy-makers from 17 countries, including 7 LMIC’s.

Deborah F. King
Helen Groves
David C. Kaslow
News & ViewsOpen Access29 Apr 2024
npj Vaccines

Volume: 9, P: 1-9

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Multicohort assessment of plasma metabolic signatures of tuberculosis disease in children: a retrospective cross-sectional study

Ebola vaccine safe for mothers and infants

Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa

Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice

High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia

Publisher Correction: Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life

Women and children last? Shaking up exclusion criteria for vaccine trials

Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants

Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023

Keeping track of the SARS-CoV-2 vaccine pipeline

Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis

Respiratory syncytial, parainfluenza and influenza virus infection in young children with acute lower respiratory infection in rural Gambia

Immunization: vital progress, unfinished agenda

Acquisition and carriage of genetically diverse multi-drug resistant gram-negative bacilli in hospitalised newborns in The Gambia

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries

Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India

Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India

Realising the potential of correlates of protection for vaccine development, licensure and use: short summary

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