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Advanced filters: Author: Beatriz Herguedas Clear advanced filters

GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins

Vega-Gutiérrez et al. present cryo-electron microscopy structures of GluA4-containing AMPA receptors, which are key for brain signaling. They show GluA4-specific conformations and explain how subunit composition shapes receptor architecture, dynamics and function.

Carlos Vega-Gutiérrez
Javier Picañol-Párraga
Beatriz Herguedas
Research15 Sept 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2416-2428
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor

AMPA glutamate receptors, mediate the majority of excitatory signaling in the brain. Here the authors show how the auxiliary subunit TARP-γ8 shapes gating kinetics, ion conductance and rectification properties of the heteromeric GluA1/2 AMPA receptor.

Beatriz Herguedas
Bianka K. Kohegyi
Ingo H. Greger
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-12
Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors

The GluA3 homomer substantially diverges from other AMPA-type glutamate receptors.

Aditya Pokharna
Imogen Stockwell
Ingo H. Greger
ResearchOpen Access01 Jul 2025
Nature

Volume: 645, P: 535-543
The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes

Ana Serrano
María Sebastián
Milagros Medina
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-13