Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Beeke Wienert Clear advanced filters

  • Adult expression of fetal haemoglobin is beneficial and thus desirable in patients with haemoglobin disorders. Here the authors introduce a naturally occurring mutation in the γ-globinpromoter and show that it causes binding of an activator TAL1, chromosome looping and revival of fetal haemoglobin expression in erythroid cells.

    • Beeke Wienert
    • Alister P. W. Funnell
    • Merlin Crossley
    Research
    Nature Communications
    Volume: 6, P: 1-8

  • The authors describe DISCOVER-seq, a method to detect off-targets of CRISPR–Cas genome editing based on ChIP-seq analysis of MRE11 recruitment to DSBs, and subsequent bioinformatics analysis of sequencing data using the BLENDER pipeline.

    • Beeke Wienert
    • Stacia K. Wyman
    • Jacob E. Corn
    Protocols
    Nature Protocols
    Volume: 15, P: 1775-1799

  • Altering cellular responses to double-strand breaks in DNA could rebalance CRISPRediting outcomes. Here, the authors use a pooled CRISPR screen to identify inhibition of CDC7 as a strategy to improve HDR outcomes.

    • Beeke Wienert
    • David N. Nguyen
    • Jacob E. Corn
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15