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Showing 1–2 of 2 results
Advanced filters: Author: Belul Assefa Shifa Clear advanced filters

  • This report identifies LMTK3 kinase as a regulator of ERα activity. LMTK3 exerts its effects through direct interaction and indirectly through regulation of PKC, AKT and FOXO3's effects on ERα transcription and stability. LMTK3 can modulate tamoxifen responses and is a poor prognostic factor in human breast cancer.

    • Georgios Giamas
    • Aleksandra Filipović
    • Justin Stebbing
    Research
    Nature Medicine
    Volume: 17, P: 715-719

  • The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they differently affect development, tissue growth and tumor suppression.

    • Yavuz Kulaberoglu
    • Kui Lin
    • Alexander Hergovich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16