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Showing 1–22 of 22 results
Advanced filters: Author: Ben F. Luisi Clear advanced filters

  • Small regulatory RNAs can act on target mRNAs to control their translation and stability. Here, the authors present evidence that this riboregulation can potentially regulate by pairing to a target site within translation initiation complex and translation-transcription assemblies.

    • Johann J. Roske
    • Giulia Paris
    • Ben F. Luisi
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram averaging.

    • Xiaodong Shi
    • Muyuan Chen
    • Zhao Wang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-6

  • Water molecules and DNA conformation are now recognized as ingredients which can influence both the affinity and specificity of protein/DNA complexes.

    • Nicola D. Arbuckle
    • Ben Luisi
    News & Views
    Nature Structural Biology
    Volume: 2, P: 341-346

  • Hfq is a bacterial RNA-binding protein that participates in post-transcriptional control of gene expression by facilitating the interactions between small non-coding RNAs and their target mRNAs. In this Review, Vogel and Luisi describe the structural and functional features of this protein and discuss possible mechanisms of Hfq-mediated regulation.

    • Jörg Vogel
    • Ben F. Luisi
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 578-589

  • 5-Formylcytosine (5fC) is implicated in active DNA demethylation and has been proposed to act as an epigenetic signal. Balasubramanian and colleagues now report that this base modification imparts a unique, previously undescribed conformation to DNA.

    • Eun-Ang Raiber
    • Pierre Murat
    • Shankar Balasubramanian
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 44-49

  • Mitochondrial tRNAs are less structurally stable than nuclear tRNAs, and their maturation pathway is unique. Here, the authors reveal how human mitochondrial precursor tRNAs are recognised, processed, methylated and prepared for full functionality in mitochondrial translation.

    • Vincent Meynier
    • Steven W. Hardwick
    • Carine Tisné
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Bacteria have toxin-antitoxin systems that can trigger cell death upon different conditions, including phage infection. The recently identified type III TA system consists of an RNA endonuclease toxin and an RNA antitoxin, and the crystal structure of the complex is now presented.

    • Tim R Blower
    • Xue Y Pei
    • George P C Salmond
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 185-190

  • Pdr5 is an ABC transporter conferring multidrug resistance to pathogenic fungi. Here, structural analysis of Pdr5 provides insights into the transport mechanism featuring asymmetric movements of Pdr5 domain and enabling efflux of a broad spectrum of compounds.

    • Andrzej Harris
    • Manuel Wagner
    • Lutz Schmitt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • An approach for the design of protein pores is demonstrated by the computational design and subsequent experimental expression of both an ion-selective and a large transmembrane pore.

    • Chunfu Xu
    • Peilong Lu
    • David Baker
    Research
    Nature
    Volume: 585, P: 129-134

  • Metabolites act as enzyme inhibitors, but their global impact on metabolism has scarcely been considered. Here, the authors generate a human genome-wide metabolite-enzyme inhibition network, and find that inhibition occurs largely due to limited structural diversity of metabolites, leading to a global constraint on metabolism which subcellular compartmentalization minimizes.

    • Mohammad Tauqeer Alam
    • Viridiana Olin-Sandoval
    • Markus Ralser
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the structure of one such pump, AcrAB–TolC, is determined using X-ray crystallography and cryo-electron microscopy.

    • Dijun Du
    • Zhao Wang
    • Ben F. Luisi
    Research
    Nature
    Volume: 509, P: 512-515

  • One factor contributing to the emergence of antimicrobial resistance is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. This Review describes recent insights into the structure, function and regulation of efflux pumps.

    • Dijun Du
    • Xuan Wang-Kan
    • Ben F. Luisi
    Reviews
    Nature Reviews Microbiology
    Volume: 16, P: 523-539

  • In this Review, the authors describe how Toll-like receptors (TLRs) assemble with signalling adaptor proteins to form higher-order scaffolds that signal in response to pathogen sensing. Productive TLR signalling involves cooperative assembly, post-translational modification and subcellular localization of the components of the signalling complexes.

    • Nicholas J. Gay
    • Martyn F. Symmons
    • Clare E. Bryant
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 546-558