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Showing 1–2 of 2 results
Advanced filters: Author: Ben Haspels Clear advanced filters

  • Haspels et al. developed a high-throughput assay facilitated by automatic spheroid segmentation using deep learning. Measured differences in treatment response between cisplatin-sensitive and resistant tumors faithfully correspond with expected in vivo responses and the assay is able to discriminate between olaparib-sensitive and resistant tumors.

    • Ben Haspels
    • Maarten W. Paul
    • Maayke M. P. Kuijten
    ResearchOpen Access
    Communications Medicine
    P: 1-12

  • Hereditary nucleotide excision repair deficiencies cause different cancerous and progeroid disorders of which the exact etiology is not understood. This study finds that prolonged binding of DNA repair factor TFIIH to DNA damage contributes to a more severe phenotype caused by DNA repair deficiency.

    • Alba Muniesa-Vargas
    • Carlota Davó-Martínez
    • Hannes Lans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16