Dipeptidyl-peptidase 6 is implicated in different neuropsychiatric pathologies. Lin and colleagues genetically delete dipeptidyl-peptidase 6 in mice and find that this results in impaired development of dendritic filopodia, as well as a reduction in the dendritic tree size, spine density and functional synapses.
- Lin Lin
- Wei Sun
- Dax A. Hoffman