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Showing 1–3 of 3 results
Advanced filters: Author: Ben W. Dulken Clear advanced filters
  • Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.

    • Ben W. Dulken
    • Matthew T. Buckley
    • Anne Brunet
    Research
    Nature
    Volume: 571, P: 205-210
  • An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the same differentiation path as embryonic neurogenesis, but the cell of origin differs. This work provides an invaluable resource with important implications for neuronal regeneration.

    • Ben W. Dulken
    • Anne Brunet
    News & Views
    Nature Neuroscience
    Volume: 21, P: 159-160
  • Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

    • Sydney R. Gordon
    • Roy L. Maute
    • Irving L. Weissman
    Research
    Nature
    Volume: 545, P: 495-499