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Showing 1–11 of 11 results
Advanced filters: Author: Benedikt M. Beckmann Clear advanced filters

  • The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological changes that occur following different drug treatments.

    • Johannes Betge
    • Niklas Rindtorff
    • Michael Boutros
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • RNA-binding proteins (RBPs) are implicated in many biological functions. Here the authors expand the human and yeast RNA interactome identifying new and conserved RBPs, several of which with no prior function assigned to RNA biology or structural motifs known to mediate RNA-binding, and suggesting new roles of RNA as modulators of protein function.

    • Benedikt M. Beckmann
    • Rastislav Horos
    • Matthias W. Hentze
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • RNA-binding proteins play key roles in controlling gene expression in many organisms. Here, Chu et al. identify hundreds of RNA-binding proteins in methicillin-resistant Staphylococcus aureus, and show that a major transcription factor uses its helix-turn-helix domain to bind RNAs near intrinsic transcription terminators.

    • Liang-Cui Chu
    • Pedro Arede
    • Sander Granneman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • RNA binding proteins are important regulators of RNA function. Here the authors describe a method for isolation of RNA-protein complexes that does not rely on a specific RNA sequence or motif, and demonstrate the approach by providing the global RNA-bound proteomes of human HEK293 cells and Salmonella Typhimurium.

    • Erika C. Urdaneta
    • Carlos H. Vieira-Vieira
    • Benedikt M. Beckmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmonary cellular responses.

    • Geraldine Nouailles
    • Emanuel Wyler
    • Martin Witzenrath
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Modern high-resolution X-ray microscopy techniques suffer from limited field-of-view or longer acquisition times. Here the authors use structured illumination to enable fast, full-field super-resolution transmission microscopy, even for optically thick specimens and at hard X-ray energies.

    • Benedikt Günther
    • Lorenz Hehn
    • Franz Pfeiffer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Seagrass meadows are important carbon sinks. Here, the authors show that organic carbon in the form of simple sugars can accumulate at high concentrations in seagrass rhizospheres because plant phenolic compounds inhibit their consumption by microorganisms.

    • E. Maggie Sogin
    • Dolma Michellod
    • Manuel Liebeke
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 6, P: 866-877

  • A correlative imaging approach in which matrix-assisted laser desorption ionization mass spectrometry imaging is followed by fluorescence in situ hybridization (metaFISH) for the spatial metabolomics identification of host–microbiome interactions, at single-cell resolution, via nucleic acid probes.

    • Patric Bourceau
    • Benedikt Geier
    • Manuel Liebeke
    Protocols
    Nature Protocols
    Volume: 18, P: 3050-3079