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Natural killer cells in antiviral immunity

This Review covers the role of natural killer cells in acute and chronic viral infections, with emphasis on human infections and insights from patients with primary immunodeficiencies affecting natural killer cells. It also describes the emerging data on how natural killer cells are involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Niklas K. Björkström
Benedikt Strunz
Hans-Gustaf Ljunggren
Reviews11 Jun 2021
Nature Reviews Immunology

Volume: 22, P: 112-123
Transient tissue residency and lymphatic egress define human CD56^bright NK cell homeostasis

Here the authors map the dynamics of human NK cell residency and recirculation, showing that CD56^bright NK cells transiently occupy tissues and recirculate via lymphatics, whereas CD56^dim NK cells remain vascular except during inflammation.

Annika Niehrs
Laura Hertwig
Niklas K. Björkström
ResearchOpen Access14 Oct 2025
Nature Immunology

Volume: 26, P: 2004-2015
Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.

Benedikt Strunz
Julia Hengst
Niklas K. Björkström
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Plasma FABP4 is associated with liver disease recovery during treatment-induced clearance of chronic HCV infection

Jean-Baptiste Gorin
David F. G. Malone
Johan K. Sandberg
ResearchOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Human resident liver myeloid cells protect against metabolic stress in obesity

Barreby et al. identify a distinct subpopulation of human resident liver myeloid cells that expresses factors that act in a protective fashion against oxidative stress associated with NAFLD.

Emelie Barreby
Benedikt Strunz
Myriam Aouadi
ResearchOpen Access06 Jul 2023
Nature Metabolism

Volume: 5, P: 1188-1203
The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19

Benedikt Strunz
Pouria Momayyezi
Quirin Hammer
ResearchOpen Access01 Nov 2024
Genes & Immunity

Volume: 26, P: 70-74
Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae

Jonna Bister
Ylva Crona Guterstam
Niklas K. Björkström
Research05 Aug 2020
Mucosal Immunology

Volume: 14, P: 357-365

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Natural killer cells in antiviral immunity

Transient tissue residency and lymphatic egress define human CD56^bright NK cell homeostasis

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Plasma FABP4 is associated with liver disease recovery during treatment-induced clearance of chronic HCV infection

Human resident liver myeloid cells protect against metabolic stress in obesity

The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19

Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae

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Natural killer cells in antiviral immunity

Transient tissue residency and lymphatic egress define human CD56bright NK cell homeostasis

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Plasma FABP4 is associated with liver disease recovery during treatment-induced clearance of chronic HCV infection

Human resident liver myeloid cells protect against metabolic stress in obesity

The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19

Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae

Search

Quick links

Transient tissue residency and lymphatic egress define human CD56^bright NK cell homeostasis