Nanopore electrical detection has shown potential in sensing subtle protein and peptide conformation changes, and its sensitivity makes it promising for point-of-care applications. In this Review, the authors discuss the capability of nanopore sensing for detecting and quantifying conformational modifications and enantiomers in biomarker proteins and peptides, as well as the practicalities and challenges for this approach to be used for clinical and point-of-care diagnosis.
- Laura Ratinho
- Nathan Meyer
- Juan Pelta