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Showing 1–4 of 4 results
Advanced filters: Author: Benjamin Fook Lun Lai Clear advanced filters

  • Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.

    • Yimu Zhao
    • Shira Landau
    • Milica Radisic
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 588-608

  • This protocol describes how to integrate organoids into a vascularized organ-on-a-chip biofabricated platform. The platform is assembled in a 96-well format and allows the connection of two tissues through a single endothelialized microchannel blood vessel.

    • Benjamin Fook Lun Lai
    • Rick Xing Ze Lu
    • Milica Radisic
    Protocols
    Nature Protocols
    Volume: 16, P: 2158-2189

  • Organ-on-a-chip devices can recreate key aspects of human physiology in vitro, offering an alternative to animal models for preclinical drug testing. This Review examines how tissue barrier properties, parenchymal tissue function and multi-organ interactions can be recreated in organ-on-a-chip systems and applied for drug screening.

    • Boyang Zhang
    • Anastasia Korolj
    • Milica Radisic
    Reviews
    Nature Reviews Materials
    Volume: 3, P: 257-278