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Showing 1–11 of 11 results
Advanced filters: Author: Benjamin M. Gaub Clear advanced filters

  • Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has faster kinetics than others and show that it resolves some of these difficulties in a mouse model.

    • Michael H. Berry
    • Amy Holt
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.

    • Michael H. Berry
    • Amy Holt
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Here, the authors combined and synchronized single-cell nanoindentation, electrophysiology and functional fluorescence imaging to evaluate the responses of neuronal networks to mechanical stimuli with piconewton force sensitivity and nanometre precision, enabling the exploration of nanomechanobiology and manipulation of neuronal systems.

    • Krishna Chaitanya Kasuba
    • Alessio Paolo Buccino
    • Daniel J. Müller
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 19, P: 825-833

  • Light-sensitive ligands can be used to regulate neurobiological receptors with high spatiotemporal precision. Here, the optochemical control of neuronal nicotinic acetylcholine receptors, using both photoswitchable tethered agonists and antagonists, is described. These rationally designed hybrid photoreceptors will facilitate the investigation of the physiological and pathological functions of nicotinic receptors in the brain.

    • Ivan Tochitsky
    • Matthew R. Banghart
    • Dirk Trauner
    Research
    Nature Chemistry
    Volume: 4, P: 105-111

  • Stretch-activated ion channel Piezo1 contribures to mechanotransduction in many tissues, but its output is mostly measured indirectly. Here, the authors introduce GenEPi, a fluorescent reporter for directly visualizing Piezo1 activation-dependent calcium influx.

    • Sine Yaganoglu
    • Konstantinos Kalyviotis
    • Periklis Pantazis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Mechanobiology describes how biological systems respond to mechanical stimuli. This Review surveys basic principles, advantages and limitations of applying and combining atomic force microscopy-based modalities with complementary techniques to characterize the morphology, mechanical properties and functional response of complex biological systems to mechanical cues.

    • Michael Krieg
    • Gotthold Fläschner
    • Daniel J. Müller
    Reviews
    Nature Reviews Physics
    Volume: 1, P: 41-57

  • A picobalance consisting of an optically excited microcantilever has been developed and used to measure the masses of individual healthy and virus-infected cells at high temporal and mass resolutions in culture conditions.

    • David Martínez-Martín
    • Gotthold Fläschner
    • Daniel J. Müller
    Research
    Nature
    Volume: 550, P: 500-505

  • This Technical Report describes light-activatable metabotropic glutamate receptors based on synthetic photoswitchable tethered ligands, and demonstrates optogenetic control of G protein–coupled receptor activity in neurons in vivo and ex vivo.

    • Joshua Levitz
    • Carlos Pantoja
    • Ehud Y Isacoff
    Research
    Nature Neuroscience
    Volume: 16, P: 507-516