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Showing 1–7 of 7 results
Advanced filters: Author: Benjamin N. Bimber Clear advanced filters

  • Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.

    • Benjamin J. Burwitz
    • Jochen M. Wettengel
    • Jonah B. Sacha
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Here, the authors show that neutralization of human sera from both BNT162b2 vaccine recipients and from convalescent COVID-19 patients is less efficient against SARS- CoV-2 variants B.1.1.7 and B.1.351 and negatively associated with patient age.

    • Timothy A. Bates
    • Hans C. Leier
    • Fikadu G. Tafesse
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7

  • CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.

    • Xiao L. Chang
    • Gabriela M. Webb
    • Jonah B. Sacha
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Here the authors deliver aerosolized human monoclonal antibodies to SARS-CoV-2-infected rhesus macaques and show that the treatment significantly reduces viral RNA and infectious virus in the respiratory tracts, limits lung pathology, and decreases inflammatory cytokines.

    • Daniel N. Streblow
    • Alec J. Hirsch
    • Nancy L. Haigwood
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Nonhuman primates are key preclinical models for infectious disease, vaccine development and transplantation research, but their use has been hampered by the complexity and diversity of their major histocompatibility complex (MHC) class I genotypes. Wiseman and his colleagues provide a cost-effective solution to this problem using a next-generation pyrosequencing approach to high-resolution MHC genotyping in various nonhuman primates, identifying both known and new MHC class I alleles.

    • Roger W Wiseman
    • Julie A Karl
    • David H O'Connor
    Research
    Nature Medicine
    Volume: 15, P: 1322-1326

  • Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.

    • Benjamin J. Burwitz
    • Helen L. Wu
    • Jonah B. Sacha
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10