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Showing 1–9 of 9 results
Advanced filters: Author: Benjamin R. Lichman Clear advanced filters

  • The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norcoclaurine synthase and its engineered variants.

    • Benjamin R. Lichman
    • Jianxiong Zhao
    • John M. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Unlike squalene, peplusol is only synthesized in a few species of the Euporbia genus and its biosynthetic pathway is unclear. Here, the authors report the discovery and characterization of two peplusol synthases and demonstrate the feasibility of the evolution of peplusol synthase from the ancient squalene synthase.

    • Tomasz Czechowski
    • Yi Li
    • Ian A. Graham
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone stereoisomers, as a versatile system for the production of the iridoid natural product scaffold.

    • Néstor J. Hernández Lozada
    • Benke Hong
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The incorporation of nitrogen in steroidal glycoalkaloids is hypothesized to occur through a transamination reaction. Here, the authors show that GLYCOALKALOID METABOLISM12 appears to evolve from the canonical γ-aminobutyric acid transaminases and directs the biosynthesis of nitrogen-containing steroidal metabolites in Solanum plants.

    • Dagny Grzech
    • Samuel J. Smit
    • Prashant D. Sonawane
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 131-142

  • The antinutrient pyrimidines vicine and convicine are causative agents of favism in faba bean. They have surprising biosynthetic origins in purine biosynthesis, and the generation of the antinutrient-free faba bean varieties is now on the horizon.

    • Kaouthar Eljounaidi
    • Benjamin R. Lichman
    News & Views
    Nature Plants
    Volume: 7, P: 860-861

  • A class of nepetalactol-related short-chain dehydrogenase/reductases (NEPS) captures a reactive enol intermediate produced by iridoid synthase for cyclization and subsequent oxidation into nepetalactones, the active ingredients in catnip.

    • Benjamin R. Lichman
    • Mohamed O. Kamileen
    • Sarah E. O’Connor
    Research
    Nature Chemical Biology
    Volume: 15, P: 71-79

  • The 1-aryl-tetrahydroisoquinoline moiety is a desirable synthetic target, but generating single enantiomers of THIQ products is synthetically challenging. Here the authors demonstrate that the M97V variant of enzyme norcoclaurine synthase catalyzes the synthesis of (1 S)-aryl-THIQs in high yields and enantiomeric excesses.

    • Rebecca Roddan
    • Altin Sula
    • Helen C. Hailes
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-10

  • Fish can regenerate nephrons (the functional units of the kidney) de novo after kidney injury, whereas adult mammals lack this ability. This study identifies a pool of self renewing nephron stem/progenitor cells that are responsible for nephrogenesis during kidney growth and regeneration in zebrafish. The findings might provide an insight into how mammalian renal regeneration may be therapeutically activated.

    • Cuong Q. Diep
    • Dongdong Ma
    • Alan J. Davidson
    Research
    Nature
    Volume: 470, P: 95-100