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Showing 1–5 of 5 results
Advanced filters: Author: Benjamin S. Padman Clear advanced filters

  • Here the authors show that loss of TANGO2, a gene linked to an autosomal recessive disorder characterised by developmental delay, rhabdomyolysis, cardiac arrhythmias and metabolic disturbances, disrupts mitochondrial and cytoskeletal structure by impairing its interaction with CRYAB, leading to desmin aggregation and desminopathy, causing cardiomyopathy, muscle weakness, and metabolic dysfunction in mice and human cells.

    • Maike Stentenbach
    • Laetitia A. Hughes
    • Aleksandra Filipovska
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional receptors and amplify mitophagy.

    • Benjamin Scott Padman
    • Thanh Ngoc Nguyen
    • Michael Lazarou
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent hyperactivation of PINK1/Parkin mitophagy while promoting the pathway once set in motion.

    • Elias Adriaenssens
    • Thanh Ngoc Nguyen
    • Sascha Martens
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1717-1731

  • Low frequency intrinsic ocean variability has an unknown impact on Antarctic ice shelves, yet can arise even in the absence of varying climate forcing. Here, the authors show that this variability significantly affects modelled basal melting under the Totten Ice Shelf, with implications for the attribution of change.

    • David E. Gwyther
    • Terence J. O’Kane
    • Jamin S. Greenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8