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Showing 1–3 of 3 results
Advanced filters: Author: Benjamin Stordy Clear advanced filters

  • Liver macrophages are a major obstacle to extrahepatic drug delivery. This study identifies the receptor–ligand interactions that they use to capture circulating nanoparticles and leverages this understanding to engineer nanoparticles that escape macrophage uptake.

    • Bram Bussin
    • Marshall G. G. MacDuff
    • Warren C. W. Chan
    Research
    Nature Nanotechnology
    Volume: 20, P: 914-925

  • Tumour endothelial cell macropinocytosis is the dominant mechanism for nanoparticle entry into the tumour. Enhanced nanoparticle tumour accumulation may be due to upregulated macropinocytosis membrane ruffling compared with most healthy tissues.

    • Jamie L. Y. Wu
    • Qin Ji
    • Warren C. W. Chan
    Research
    Nature Nanotechnology
    Volume: 20, P: 672-682

  • Nanoparticle retention inside tumours has been associated with lymphatic vessel collapse. It is now shown that nanoparticles exit from solid tumours through lymphatic vessels in or surrounding the tumour by a nanoparticle-size-dependent mechanism.

    • Luan N. M. Nguyen
    • Zachary P. Lin
    • Warren C. W. Chan
    Research
    Nature Materials
    Volume: 22, P: 1261-1272