Zhang et al. show increased blood concentration of IGFBP7 in patients and a mouse model with heart failure (HF). IGFBP7 promotes cardiac senescence by stimulating IGF-1R/IRS/AKT-dependent suppression of FOXO3a, and Igfbp7 deficiency or inhibition attenuates cardiac dysfunction in a pressure overload mouse HF model, suggesting that therapeutic targeting of IGFBP7 might be promising for the treatment of HF.
- Liyong Zhang
- David Smyth
- Peter P. Liu
