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Advanced filters: Author: Bernadette Bracken Clear advanced filters

The strength and pattern of natural selection on gene expression in rice

Phenotypic selection analysis is used to estimate the type and strength of selection that acts on more than 15,000 transcripts in rice (Oryza sativa), which provides insight into the adaptive evolutionary role of selection on gene expression.

Simon C. Groen
Irina Ćalić
Michael D. Purugganan
Research12 Feb 2020
Nature

Volume: 578, P: 572-576
Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens

ECCITE-seq, which combines pooled CRISPR screens with single-cell mRNA and surface protein measurements, and the computational framework mixscape identify new regulation mechanisms of PD-L1 expression.

Efthymia Papalexi
Eleni P. Mimitou
Rahul Satija
Research01 Mar 2021
Nature Genetics

Volume: 53, P: 322-331
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

Droplet-based single-cell RNA-seq is a powerful tool for cellular heterogeneity profiling in disease but is limited by instrumentation required. Here the authors develop a 3D printed microfluidic platform for massive parallel sequencing of rheumatoid arthritis tissues.

William Stephenson
Laura T. Donlin
Rahul Satija
ResearchOpen Access23 Feb 2018
Nature Communications

Volume: 9, P: 1-10