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Showing 1–2 of 2 results
Advanced filters: Author: Bernadette Tiberi Clear advanced filters

  • Using structural, biochemical, and functional assays, the authors demonstrate that the E3 ligase KLHDC2, via newly developed small-molecule ligands, can be co-opted to target critical targets for degradation.

    • Christopher M. Hickey
    • Katherine M. Digianantonio
    • Miklós Békés
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 311-322

  • Various endogenous and pathogen-derived stimuli trigger the assembly of cytosolic multimolecular 'speck' platforms coordinated by the adapter ASC. Latz and colleagues demonstrate that ASC specks have extracellular functions that can prolong inflammation.

    • Bernardo S Franklin
    • Lukas Bossaller
    • Eicke Latz
    Research
    Nature Immunology
    Volume: 15, P: 727-737