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Showing 1–13 of 13 results
Advanced filters: Author: Bernardo Rodriguez-Iturbe Clear advanced filters

  • Since publication of the first issue of Nature Reviews Nephrology 20 years ago, advances across various subspecialities of nephrology have provided insights into disease processes and led to the development of new therapeutics for people with kidney disease. However, despite this progress, many kidney diseases remain untreatable, the costs of kidney disease care are immense, and vast inequities persist in disease burden and access to care. In this Viewpoint, we ask experts from several key subspecialties of nephrology to reflect on progress made over the past 20 years, remaining challenges and the steps needed to move the field forward.

    • Urmila Anandh
    • Hans-Joachim Anders
    • Motoko Yanagita
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 727-735

  • Here, the concept of a self-perpetuating cyclical interaction between outcomes of oxidative stress (such as production of reactive oxygen species and depletion of antioxidants) and inflammatory mediators (such as cytokines), driving initiation and progression of hypertension, is presented. Experimental evidence to support operation of such a cycle is outlined, and the therapeutic implications of targeting the interactions therein are discussed.

    • Nosratola D Vaziri
    • Bernardo Rodríguez-Iturbe
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 2, P: 582-593

  • The underlying cause of hypertension is unknown in the vast majority of patients with high blood pressure. This Perspectives article discusses the role of T cells in renal inflammation and how autoimmunity, mediated by heat shock proteins, leads to salt-sensitive hypertension.

    • Bernardo Rodríguez-Iturbe
    • Héctor Pons
    • Richard J. Johnson
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 56-62

  • The degree to which systolic blood pressure should be lowered in individuals with mild hypertension is unclear. The Cardio-Sis trial has investigated whether tight systolic blood pressure control is more beneficial than usual control in individuals with hypertension but without diabetes.

    • Richard J. Johnson
    • Laura G. Sánchez-Lozada
    • Bernardo Rodríguez-Iturbe
    News & Views
    Nature Reviews Nephrology
    Volume: 5, P: 675-676

  • Recurrent dehydration and salt loss might be a mechanism that causes chronic kidney disease, whereby increased plasma osmolarity activates both intrarenal (polyol-fructokinase) and extrarenal (vasopressin) pathways to drive injury. The authors propose that water and salt influence blood pressure through the timing and combination of their intake, affecting plasma osmolarity and intrarenal and extrarenal mechanisms of renal injury.

    • Richard J. Johnson
    • Bernardo Rodriguez-Iturbe
    • Laura G. Sanchez-Lozada
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 415-420

  • Although most nephrologists spend their days managing patients with acute and chronic kidney disease (CKD), it is useful to occasionally consider the landscape of our current treatment approach. Here, we present the hypothesis that the major mechanisms that drive CKD are changing and will necessitate new approaches to manage this disease.

    • Richard J. Johnson
    • Bernardo Rodriguez-Iturbe
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 14, P: 411-412

  • Chronic kidney disease is the progressive and irreversible loss of kidney function. In this Primer, Romagnani et al. describe the epidemiology and pathophysiology of this disease, and summarize its diagnosis and management, explaining how understanding and treating all modifiable risk factors can slow the progression of chronic kidney disease and prevent or attenuate its consequences.

    • Paola Romagnani
    • Rajiv Agarwal
    • Hans-Joachim Anders
    Reviews
    Nature Reviews Disease Primers
    Volume: 11, P: 1-23

  • Fructose might be a Clue to the Origin of Preeclampsia Insights from Nature and Evolution Preeclampsia is a hypertensive disorder of pregnancy. The pathogenesis remains unclear. Fructose has a critical role in fetal growth in early pregnancy, and might be a key role to developing preeclampsia. Here, we summarize the previous literatures regarding the physiological andpathological roles of fructose in pregnancy to propose studies to further investigate the pathogenesis of preeclampsia.

    • Takahiko Nakagawa
    • Ana Andres-Hernando
    • Richard J. Johnson
    Reviews
    Hypertension Research
    Volume: 46, P: 646-653