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Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice

Luc J.W. van der Laan
Christopher Lockey
Daniel R. Salomon
Research07 Sept 2000
Nature

Volume: 407, P: 90-94
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

Bernhard J Hering
Martin Wijkstrom
Henk-Jan Schuurman
Research19 Feb 2006
Nature Medicine

Volume: 12, P: 301-303
Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular correlates of tolerance induction.

Amar Singh
Sabarinathan Ramachandran
Bernhard J. Hering
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-16
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

All forms of diabetes eventually lead to a reduction in insulin-secreting pancreatic β-cells. Here, the authors report aminopyrazine derivatives, which induce proliferation of rodent as well as human β-cells and improve glucose metabolism in a mouse model of type 1 diabetes.

Weijun Shen
Brandon Taylor
Bryan Laffitte
ResearchOpen Access26 Oct 2015
Nature Communications

Volume: 6, P: 1-11
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Sally C. Kent
Yahua Chen
David A. Hafler
Research12 May 2005
Nature

Volume: 435, P: 224-228
Sustained benefits of islet transplants for T1DM

In a retrospective multicentre study of patients with type 1 diabetes mellitus, islet transplantation was associated with sustained HbA_1c levels of <7% and freedom from severe hypoglycaemia for 5 years in 60% of immunosuppressed recipients, including those with recurrent severe pretransplant hypoglycaemia. Will islet transplant utilization in patient care now expand?

Bernhard J. Hering
Melena D. Bellin
News & Views04 Aug 2015
Nature Reviews Endocrinology

Volume: 11, P: 572-574
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes

Yu et al. report a preparation that enables transplantation of pancreatic islets underneath the skin and achieves long-term euglycaemia in several preclinical models of type 1 diabetes, thus providing a simple method that might enable a more widespread adoption of islet transplantation in the clinic.

Ming Yu
Divyansh Agarwal
Ali Naji
Research07 Sept 2020
Nature Metabolism

Volume: 2, P: 1013-1020
On the role of ocular torsion in binocular visual matching

Bernhard J. M. Hess
ResearchOpen Access13 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Capecitabine in hormone-resistant metastatic prostatic carcinoma – a phase II trial

R Morant
J Bernhard
H-P Schmid
ResearchOpen Access09 Mar 2004
British Journal of Cancer

Volume: 90, P: 1312-1317
Serum cytokine profiles in healthy nonhuman primates are blunted by sedation and demonstrate sexual dimorphism as detected by a validated multiplex immunoassay

Laura Hocum Stone
Scott Hunter Oppler
Melanie L. Graham
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-15

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