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Showing 1–16 of 16 results
Advanced filters: Author: Bernhard Lehner Clear advanced filters

  • Here the authors develop a novel statistical method for quantifying mutation burden from whole genome sequencing data and use it to discover the genetic, genomic, and phenotypic correlates of clonal hematopoiesis without known driver genetic lesions.

    • Joshua S. Weinstock
    • Sharjeel A. Chaudhry
    • Marios Arvanitis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Lakes play a key role in our ecosystems and thus it is vital to understand their distribution and volume. Here, the authors present a new global lake database (HydroLAKES) and develop a new geo-statistical model to show global lake area, shoreline length, water volume and hydraulic residence times.

    • Mathis Loïc Messager
    • Bernhard Lehner
    • Oliver Schmitt
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • A comprehensive assessment of the world’s rivers and their connectivity shows that only 37 per cent of rivers longer than 1,000 kilometres remain free-flowing over their entire length.

    • G. Grill
    • B. Lehner
    • C. Zarfl
    Research
    Nature
    Volume: 569, P: 215-221

  • An atlas of European river barriers has been made, by curating and correcting existing records, and by surveying 2,700 kilometres of waterways. It reveals that rivers are fragmented by an amazing number of obstructions.

    • Christiane Zarfl
    • Bernhard Lehner
    News & Views
    Nature
    Volume: 588, P: 395-396

  • Non-perennial rivers and streams are mapped globally, showing that more than half of rivers worldwide experience no flow for at least one day per year.

    • Mathis Loïc Messager
    • Bernhard Lehner
    • Thibault Datry
    Research
    Nature
    Volume: 594, P: 391-397

  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93

  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121

  • We reconstruct the spatial distribution and timing of wetland loss through conversion to seven human land uses between 1700 and 2020, elucidating the magnitude and land-use drivers of global wetland losses to improve assessments of wetland loss impacts.

    • Etienne Fluet-Chouinard
    • Benjamin D. Stocker
    • Peter B. McIntyre
    Research
    Nature
    Volume: 614, P: 281-286

  • Freshwater systems are important components of the carbon cycle, but the extent of their role in CO2 fluxes is poorly understood. Here Horgby and colleagues show that mountain streams are a surprisingly large source of CO2 to the atmosphere, with annual emissions that belie their spatial extent.

    • Åsa Horgby
    • Pier Luigi Segatto
    • Tom J. Battin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.

    • Daniel B. Grabarczyk
    • Olga A. Petrova
    • Tim Clausen
    Research
    Nature Chemical Biology
    Volume: 17, P: 1084-1092

  • In response to COVID-19, governments worldwide are implementing public health and social measures (PHSM) that substantially impact many areas beyond public health. The new field of PHSM data science collects, structures, and disseminates data on PHSM; here, we report the main achievements, challenges, and focus areas of this novel field of research.

    • Cindy Cheng
    • Amélie Desvars-Larrive
    • Sophia Alison Zweig
    Comments & OpinionOpen Access
    Scientific Data
    Volume: 9, P: 1-9