This work combines mass spectrometry imaging at high resolution with FISH for the visualization and identification of microorganisms. The authors develop a sample preparation and imaging pipeline called metaFISH to colocalize metabolite patterns with community members and apply it to a host–microbe symbiosis (mussel and its symbionts) to identify symbiosis-specific metabolites.
- Benedikt Geier
- Emilia M. Sogin
- Manuel Liebeke
