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Nature Cell Biology (1)

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Stem cells

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Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Aloia, McKie, Vernaz et al. show that during liver damage ductal cells acquire cellular plasticity by undergoing epigenetic remodelling, with TET1-mediated regulation of ErbB–MAPK and YAP–Hippo signalling.

Luigi Aloia
Mikel Alexander McKie
Meritxell Huch
Research04 Nov 2019
Nature Cell Biology

Volume: 21, P: 1321-1333

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Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

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