Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However most existing PRS are primarily trained on European ancestry populations, limiting their transferability to non-European populations. Here the authors propose a new multi-ancestry PRS method, PROSPER, to reduce disparity of PRS performance across ancestry groups.
- Jingning Zhang
- Jianan Zhan
- Nilanjan Chatterjee
