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Showing 1–6 of 6 results
Advanced filters: Author: Bertrand Llorente Clear advanced filters

  • One way of repairing a DNA break is through invasion of an end into a homologous, intact duplex, which can set up a replication fork. However, this work shows that the initial invasion events are unstable in the vicinity of the break, so that multiple rounds of invasion and dissociation can take place.

    • Catherine E. Smith
    • Bertrand Llorente
    • Lorraine S. Symington
    Research
    Nature
    Volume: 447, P: 102-105

  • This analysis of the registry database DESCAR-T of more than 3,000 pediatric and adult patients with hematological malignancies who received CAR T cell therapy in France between 2018 and 2024 shows that only one person developed a secondary T cell malignancy following CAR T cell therapy.

    • Remy Dulery
    • Vincent Guiraud
    • Roch Houot
    Research
    Nature Medicine
    Volume: 31, P: 1130-1133

  • Structure-specific endonucleases are essential to resolve DNA-replication and repair intermediates, but their uncontrolled activity would compromise genomic stability. New data show that the Holliday junction resolvase Mus81–Eme1 is activated in response to DNA damage by sequential phosphorylation by cell cycle– and DNA damage–dependent Cdc2CDK1 and Chk1 kinases, revealing how dual control restricts endonuclease activity in mitosis.

    • Pierre-Marie Dehé
    • Stéphane Coulon
    • Pierre-Henri L Gaillard
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 598-603

  • Cell cycle regulation of the two major DNA double-strand break repair pathways—NHEJ and HR—is critical for the maintenance of genome integrity. Here, Tomimatsu et al. show that phosphorylation of the nuclease EXO1 by cyclin-dependent kinases affects repair pathway choice by controlling long-range resection.

    • Nozomi Tomimatsu
    • Bipasha Mukherjee
    • Sandeep Burma
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • A small proportion of Spo11-dependent DNA double-strand breaks are ‘double cuts’—adjacent breaks that occur in concert—revealing that gap repair during meiosis includes that of DNA gaps generated by Spo11 itself.

    • Dominic Johnson
    • Margaret Crawford
    • Matthew J. Neale
    Research
    Nature
    Volume: 594, P: 572-576