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Showing 1–4 of 4 results
Advanced filters: Author: Besnik Bajrami Clear advanced filters

  • In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.

    • Peter G. Miller
    • Murugappan Sathappa
    • Benjamin L. Ebert
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • High-throughput screening identifies an inhibitor of the interaction between α- and β-subunits of the Mycobacterium tuberculosis (Mtb) tryptophan synthase, TrpAB, that allows for defining TrpAB as essential for Mtb infection, independent of a T cell response.

    • Samantha Wellington
    • Partha P Nag
    • Deborah T Hung
    Research
    Nature Chemical Biology
    Volume: 13, P: 943-950