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Showing 1–6 of 6 results
Advanced filters: Author: Bethan Lloyd-Lewis Clear advanced filters

  • The identity and origin of adult mammary stem cells has been much debated. Here, the authors use a stochastic genetic labelling approach, together with optical tissue clearing, to visualize clonal progeny and show that unipotent stem/progenitor cells contribute to adult mammary gland development.

    • Felicity M. Davis
    • Bethan Lloyd-Lewis
    • Christine J. Watson
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Three-dimensional culture systems and organoids for mammary glands are important to understand mammary gland development. Here, the authors identify conditions (including Neuregulin 1 and R-spondin 1) that allow the culture of organoids that are responsive to hormonal stimulation for up to 2.5 months.

    • Thierry Jardé
    • Bethan Lloyd-Lewis
    • Trevor C. Dale
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Lysosomal membrane permeabilization releases cathepsins to promote cell death and mammary gland involution. Sargeant et al. report that Stat3-driven phagocytic uptake of fatty acids in milk triglycerides permeabilizes lysosomes to induce cell death.

    • Timothy J. Sargeant
    • Bethan Lloyd-Lewis
    • Christine J. Watson
    Research
    Nature Cell Biology
    Volume: 16, P: 1057-1068

  • Conferences are often held at different venues and feature innovative scientific programs; however, their design rarely changes, and barriers that exclude marginalized scientists persist. We discuss why this is a problem and offer suggestions for people and organizations seeking to create more inclusive and sustainable scientific meetings.

    • Silke Blair Chalmers
    • Suzanne Madgwick
    • Felicity Mae Davis
    Comments & Opinion
    Nature Cell Biology
    Volume: 25, P: 1557-1560

  • Previous studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. A Mendelian randomization analysis suggests that the effects of adiposity may remain even when 18 potential mediators are accounted for, suggesting a lack of evidence for mediation and that other mediating pathways remain to be determined.

    • Marina Vabistsevits
    • George Davey Smith
    • Rebecca C. Richmond
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-11