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Showing 1–14 of 14 results
Advanced filters: Author: Betty Luu Clear advanced filters

  • Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medulloblastoma.

    • John J. Y. Lee
    • Ran Tao
    • Michael D. Taylor
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 88-102

  • Sequencing data from the developing cerebellum are compared with bulk sequencing data from paediatric tumours, providing insights into their potential origins and suggesting that many cerebellar tumours have their origins early in utero.

    • Maria C. Vladoiu
    • Ibrahim El-Hamamy
    • Michael D. Taylor
    Research
    Nature
    Volume: 572, P: 67-73

  • Medulloblastoma is the most common malignant brain tumour in children; having assembled over 1,000 samples the authors report that somatic copy number aberrations are common in medulloblastoma, in particular a tandem duplication of SNCAIP, a gene associated with Parkinson’s disease, which is restricted to subgroup 4α, and translocations of PVT1, which are restricted to Group 3.

    • Paul A. Northcott
    • David J. H. Shih
    • Michael D. Taylor
    ResearchOpen Access
    Nature
    Volume: 488, P: 49-56

  • Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular convergence of MYCN and cAMP signaling pathways.

    • Patryk Skowron
    • Hamza Farooq
    • Michael D. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

    • Xiaoyang Lan
    • David J. Jörg
    • Peter B. Dirks
    Research
    Nature
    Volume: 549, P: 227-232

  • Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

    • Paul A. Northcott
    • Ivo Buchhalter
    • Peter Lichter
    ResearchOpen Access
    Nature
    Volume: 547, P: 311-317

  • To address the question of whether a recurrent tumour is genetically similar to the tumour at diagnosis, the evolution of medulloblastoma has been studied in both an in vivo mouse model of clinical tumour therapy as well as in humans with recurrent disease; targeted tumour therapies are usually based on targets present in the tumour at diagnosis but the results from this study indicate that post-treatment recurring tumours (compared with the tumour at diagnosis) have undergone substantial clonal divergence of the initial dominant tumour clone.

    • A. Sorana Morrissy
    • Livia Garzia
    • Michael D. Taylor
    Research
    Nature
    Volume: 529, P: 351-357

  • Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using a combination of transcriptomic and genomic profiling of multiregional biopsies. They find that medulloblastomas have spatially homogeneous transcriptomes, whereas somatic mutations that affect genes suitable for targeted therapeutics are spatially heterogeneous.

    • A Sorana Morrissy
    • Florence M G Cavalli
    • Michael D Taylor
    Research
    Nature Genetics
    Volume: 49, P: 780-788