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Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice

Bacterial pathogens produce enterobactin, which suppresses microbiota-derived indole activation of Ahr in macrophages to inhibit bacterial clearance and increase the severity of bacterial sepsis.

Robert C. Keskey
Jason Xiao
John C. Alverdy
Research08 Jan 2025
Nature Microbiology

Volume: 10, P: 388-404
Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes

Ultrasensitive methods for detection of biomarkers for infectious disease are needed for diagnosing, monitoring and targeting treatment. Here the authors develop a digital assay for inflammatory markers, bacterial DNA and antibotic-resistance genes and apply it to characterise asthma patients and predict mortality from septic shock.

M. Fatih Abasıyanık
Krysta Wolfe
Savaş Tay
ResearchOpen Access25 May 2020
Nature Communications

Volume: 11, P: 1-12
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

Here, via applying metagenomics and metabolomics analyses, the authors show that fecal microbiota composition and microbiota-derived metabolites predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection, suggesting the gut-lung axis to play an important role in the recovery from COVID-19.

Matthew R. Stutz
Nicholas P. Dylla
Bhakti K. Patel
ResearchOpen Access03 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult mice after early life and/or adult stress

Catherine Jensen Peña
Milo Smith
Eric J. Nestler
ResearchOpen Access08 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Structural basis of AMPK regulation by small molecule activators

Small molecule activators of the energy sensing kinase AMPK are promising candidates as therapies for metabolic disease. Xiao et al. present the crystal structure of AMPK in complex with a small molecule activator, and show that the drug stabilizes interaction between the catalytic and carbohydrate-binding domains.

Bing Xiao
Matthew J. Sanders
Steven J. Gamblin
ResearchOpen Access19 Dec 2013
Nature Communications

Volume: 4, P: 1-10
STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response

Bhakti Patel
Yifan Zhou
Stephanie S. Watowich
Research11 Mar 2024
Leukemia

Volume: 38, P: 1143-1155

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Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes

Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Structural basis of AMPK regulation by small molecule activators

STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response

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