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Showing 1–2 of 2 results
Advanced filters: Author: Bhavesh Premdjee Clear advanced filters

  • Native chemical ligation (NCL) has revolutionized the field of chemical protein synthesis. This Review discusses milestones such as desulfurization, the development of thiol and selenol analogues of proteinogenic amino acids and novel acyl donors for multi-component iterative ligations. These have greatly expanded the NCL concept and enabled the synthesis of hitherto inaccessible protein targets.

    • Sameer S. Kulkarni
    • Jessica Sayers
    • Richard J. Payne
    Reviews
    Nature Reviews Chemistry
    Volume: 2, P: 1-17

  • This protocol outlines the chemical synthesis of proteins via a recently discovered reaction called diselenide–selenoester ligation (DSL) in a rapid, additive-free manner. After ligation, products can be chemoselectively deselenized to produce native peptide and protein products.

    • Sameer S. Kulkarni
    • Emma E. Watson
    • Richard J. Payne
    Protocols
    Nature Protocols
    Volume: 14, P: 2229-2257