Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Bianca V. Gapp Clear advanced filters

  • A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

    • Markus K Muellner
    • Iris Z Uras
    • Sebastian M B Nijman
    Research
    Nature Chemical Biology
    Volume: 7, P: 787-793

  • CRISPR-Cas9 has greatly enhanced genome engineering however gene tagging can still be cumbersome due to a requirement for homology donors. Here the authors introduce a generic system for gene tagging that does not require homology between the donor and the genomic target site.

    • Daniel H. Lackner
    • Alexia Carré
    • Tilmann Bürckstümmer
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • A collection of single-gene-mutant human cells is described. This growing resource is based on gene-trap mutagenesis of a near-haploid human cell line and covers almost 3,500 human genes.

    • Tilmann Bürckstümmer
    • Carina Banning
    • Sebastian M B Nijman
    Research
    Nature Methods
    Volume: 10, P: 965-971