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Nature Immunology (1)

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Transcriptional regulator SATB1 limits CD8⁺ T cell population expansion and effector differentiation in chronic infection and cancer

Kallies and colleagues examine the role of the chromatin regulator SATB1 in CD8⁺ T cell differentiation during viral infection and cancer. They show that SATB1 is a negative regulator of exhausted CD8⁺ T cell expansion and effector differentiation.

Leonie Heyden
Lisa Rausch
Axel Kallies
Research27 Oct 2025
Nature Immunology

Volume: 26, P: 2312-2327

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Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer

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Transcriptional regulator SATB1 limits CD8⁺ T cell population expansion and effector differentiation in chronic infection and cancer