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Showing 1–8 of 8 results
Advanced filters: Author: Bijay S. Jaiswal Clear advanced filters

  • Raphael Bueno, Eric Stawiski, Somasekar Seshagiri and colleagues present a comprehensive genomic analysis of malignant pleural mesothelioma. They identify four distinct molecular subtypes using RNA-seq data and highlight recurrent somatic mutations, gene fusions and splicing alterations.

    • Raphael Bueno
    • Eric W Stawiski
    • Somasekar Seshagiri
    Research
    Nature Genetics
    Volume: 48, P: 407-416

  • Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other significantly mutated genes not previously associated with gallbladder cancer.

    • Akhilesh Pandey
    • Eric W. Stawiski
    • Somasekar Seshagiri
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Somasekar Seshagiri, James Brugarolas and colleagues report the mutational landscape of 167 non–clear cell renal cell carcinomas (nccRCCs) from multiple subtypes. They identify subtype-specific driver mutations and gene fusions, including ones involving MITF, which result in expression of the anti-apoptotic protein BIRC7 and might thus indicate candidates for treatment with BIRC7 inhibitors.

    • Steffen Durinck
    • Eric W Stawiski
    • Somasekar Seshagiri
    Research
    Nature Genetics
    Volume: 47, P: 13-21

  • These authors performed a large-scale study in which they identified 2,576 somatic mutations across 1,507 coding genes from 441 breast, lung, ovarian and prostate cancer types and subtypes. The study provides an overview of the mutational spectra across major human cancers, implies an expanded role for Gα subunits in multiple cancer types and identifies several potential therapeutic targets.

    • Zhengyan Kan
    • Bijay S. Jaiswal
    • Somasekar Seshagiri
    Research
    Nature
    Volume: 466, P: 869-873

  • Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.

    • Somasekar Seshagiri
    • Eric W. Stawiski
    • Frederic J. de Sauvage
    ResearchOpen Access
    Nature
    Volume: 488, P: 660-664

  • The RAS–RAF signalling pathway is an attractive target for drug development in oncology, and several RAF inhibitors are being tested in clinical trials. Here and in an accompanying paper, RAF inhibitors are shown to have opposing roles, functioning as either inhibitors or activators of RAF depending on the cellular context and mutational status of RAF. The mechanistic basis for these opposing roles is dissected. The results have implications for the clinical use of these inhibitors and for the design of kinase inhibitors.

    • Georgia Hatzivassiliou
    • Kyung Song
    • Shiva Malek
    Research
    Nature
    Volume: 464, P: 431-435

  • Leonard Goldstein et al. use high-throughput single-cell B-cell receptor sequencing on thousands of individual B cells from rat, mouse, and human repertoires. They obtained paired full-length heavy- and light-chain variable regions, and show that this approach is a powerful tool for antibody discovery.

    • Leonard D. Goldstein
    • Ying-Jiun J. Chen
    • Somasekar Seshagiri
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10