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Showing 1–3 of 3 results
Advanced filters: Author: Bindu Hegde Clear advanced filters

  • Genome-wide CRISPR screens, biochemical studies and animal models show that RASA2 has a key role in regulating T cell function and has potential as a genetic target for enhancing anti-tumour immunity.

    • Julia Carnevale
    • Eric Shifrut
    • Alexander Marson
    ResearchOpen Access
    Nature
    Volume: 609, P: 174-182

  • Chronic exposure to silica crystals can cause lung inflammation and cancer. Here, the authors show that mast cells and macrophages respond to silica crystals by producing leukotriene B4, which recruits neutrophils leading to inflammation, and that blocking this pathway attenuates cancer progression.

    • Shuchismita R. Satpathy
    • Venkatakrishna R. Jala
    • Bodduluri Haribabu
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.

    • Rajbir Singh
    • Sandeep Chandrashekharappa
    • Venkatakrishna R. Jala
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18