Tripeptidyl peptidase II is an eukaryotic serine protease that forms huge, spindle-shaped homopolymeric complexes, whose building block is an enzymatically inactive dimer. Now a combination of cryo-EM and crystal structure analysis of Drosophila TPPII allows a view on dimer organization and polymer architecture assembly, as well as insight into the mechanism of activation.
- Crystal K Chuang
- Beate Rockel
- Bing K Jap
