Reactive oxygen species (ROS) serve as endogenous triggers for prodrugs, probes and materials, however ROS-activated bioorthogonal ligation remains as a challenge. Here, the authors report a ROS-activated tetrazine ligation enabled by boronate-caged dihydrotetrazines, and employ it for targeted protein degradation and tumor-selective drug delivery.
- Dongqing Ming
- Jiaxue Zhang
- Luping Liu
