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Showing 1–3 of 3 results
Advanced filters: Author: Biswanath Chowdhury Clear advanced filters

  • Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

    • Biswanath Chowdhury
    • Kaiyuan Zhu
    • Vineet Bafna
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • The impact of breakage fusion bridge (BFB) cycles on tumour heterogeneity and clinical outcomes remains poorly understood. Here, the authors develop OM2BFB, an algorithm to detect and reconstruct BFB amplifications using optical genome maps and use it to study BFB events across 2557 primary tumours and cancer cell lines.

    • Siavash Raeisi Dehkordi
    • Ivy Tsz-Lo Wong
    • Vineet Bafna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Convalescent plasma therapy (CPT) is used to treat patients with Covid-19, but evidence for clinical benefit from clinical trials is divergent. Here the authors report in that CPT treatment does not affect mortality in patients with severe Covid-19 in phase 2 single center open label randomised controlled trial.

    • Yogiraj Ray
    • Shekhar Ranjan Paul
    • Dipyaman Ganguly
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9