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Showing 1–3 of 3 results
Advanced filters: Author: Bjoern Schwalb Clear advanced filters

  • Molecular glue degraders (MGD) offer a way to target undruggable proteins, but their discovery is challenging. Here, the authors develop a high-throughput proteomics platform for MGD drug discovery, revealing a much larger cereblon neosubstrate space than initially thought.

    • Martin Steger
    • Gisele Nishiguchi
    • Zoran Rankovic
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Gene activation requires an increase of successful initiation events. Here, by employing a genome-wide kinetic analysis of transcription, the authors showed that gene activation generally requires a decrease in RNA Polymerase II (Pol II) promoter-proximal pausing while transcription of enhancer elements is not limited by Pol II pausing.

    • Saskia Gressel
    • Björn Schwalb
    • Patrick Cramer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • After loss of MSL2, a class of dosage-sensitive genes transitions from biallelic to monoallelic expression, whereby one allele remains active, retaining active histone modifications and transcription factor binding, and the other allele is silenced, exhibiting loss of promoter–enhancer contacts and the acquisition of DNA methylation.

    • Yidan Sun
    • Meike Wiese
    • Asifa Akhtar
    ResearchOpen Access
    Nature
    Volume: 624, P: 173-181