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Showing 1–4 of 4 results
Advanced filters: Author: Blaine Fitzgerald Clear advanced filters

  • Gene regulatory network architecture and complex dosage effects from paralogue diversification converge to shape phenotypic space, producing the potential for both strongly buffered phenotypes and sudden bursts of phenotypic change.

    • Sophia G. Zebell
    • Carlos Martí-Gómez
    • Zachary B. Lippman
    ResearchOpen Access
    Nature
    Volume: 644, P: 984-992

  • Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.

    • Yue Li
    • Norihiro Imai
    • Susan J. Hagen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57