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Showing 1–3 of 3 results
Advanced filters: Author: Blair A. Denman Clear advanced filters
  • Declining NAD+ levels have been linked to aging-associated pathologies. Here the authors present results of a double-blind, randomized crossover trial on 30 healthy middle-aged individuals to show that nicotinamide riboside effectively elevates NAD+ levels in humans, appears to be well tolerated, and may have potential to improve cardiovascular parameters.

    • Christopher R. Martens
    • Blair A. Denman
    • Douglas R. Seals
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11
  • Here, the authors report a large-scale comparative analysis of <30,000 Diversity-Generating Retroelements (DGRs) across ~9000 metagenomes (representing diverse taxa and biomes), to identify patterns in terms of prevalence and activity. Combined with examination of longitudinal data on <100 metagenomes part of time series, they demonstrate that DGRs are broadly and consistently active, implying an important role in microbiota ecology and evolution.

    • Simon Roux
    • Blair G. Paul
    • Emiley A. Eloe-Fadrosh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12